The mission house derives its significance from its association with a religious figure, Rev. H.A. Roux who established himself in 1899 at Bethlehem as the first missionary of the Dutch Reformed Church in the town. He bought the erf with the original three rooms of the building in 1903 from Rev. C.P. Theron who acquired the property in 1878. In 1904 the building was enlarged by the builder Louis Ferdinand to its current appearance. The old mission house forms part of the sandstone architecture of Bethlehem.